Metim-GP
Methylcobalamin and Gabapentin combination is useful for the treatment of neuropathic disorders or seizure disorders. Methylcobalamin is a form of vitamin B that is used to prevent postherpetic neuralgia, neuralgia intercostals, and diabetic neuropathy. Gabapentin is an anti-convulsant that prevents repeated electrical signals in the brain that cause seizures and is used to treat epilepsy or other similar disorders.
PHARMACOLOGY:
Gabapentin [1-(aminomethyl)cyclohexane acetic acid] is a novel anti-epileptic agent, originally developed as a gamma-aminobutyric acid (GABA)-mimetic compound to treat spasticity, and has been shown to have potent anticonvulsive effects. Initially approved only for use in partial seizures, it soon showed promise in the treatment of chronic pain syndromes, especially neuro-pathic pain. PHARMACOKINETICS : Gabapentin, available only as oral preparations, is absorbed in the small intestine by a combination of diffusion and facilitated transport. Its transport from the gut following oral administration is facilitated by its binding to an, as yet unidentified, receptor linked to a saturable L-amino acid transport mechanism. As this carrier-dependent transport is saturable, the bioavailability of gabapentin varies inversely with dose. Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
CONTRAINDICATION : Gabapentin is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.
SIDE EFFECTS: ♦ Headache
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